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The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases

Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation, and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide exchange factors (GEFs), of which two classes:...

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Autors principals: Droppelmann, Cristian A., Campos-Melo, Danae, Volkening, Kathryn, Strong, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159981/
https://ncbi.nlm.nih.gov/pubmed/25309324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00282
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