Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a progressive, adult onset, fatal neurodegenerative disease of motor neurons. There is emerging evidence that alterations in RNA metabolism may be critical in the pathogenesis of ALS. MicroRNAs (miRNAs) are small non-coding RNAs that are key determi...

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Autores principales: Campos-Melo, Danae, Droppelmann, Cristian A, He, Zhongping, Volkening, Kathryn, Strong, Michael J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668997/
https://ncbi.nlm.nih.gov/pubmed/23705811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-26
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