Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1(R122H)

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRS...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gui, Fu, Zhang, Yuebo, Wan, Jianhua, Zhan, Xianbao, Yao, Yao, Li, Yinghua, Haddock, Ashley N., Shi, Ji, Guo, Jia, Chen, Jiaxiang, Zhu, Xiaohui, Edenfield, Brandy H., Zhuang, Lu, Hu, Cheng, Wang, Ying, Mukhopadhyay, Debabrata, Radisky, Evette S., Zhang, Lizhi, Lugea, Aurelia, Pandol, Stephen J., Bi, Yan, Ji, Baoan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934224/
https://ncbi.nlm.nih.gov/pubmed/31550238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130172
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