Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1(R122H)

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRS...

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Publicat a:J Clin Invest
Autors principals: Gui, Fu, Zhang, Yuebo, Wan, Jianhua, Zhan, Xianbao, Yao, Yao, Li, Yinghua, Haddock, Ashley N., Shi, Ji, Guo, Jia, Chen, Jiaxiang, Zhu, Xiaohui, Edenfield, Brandy H., Zhuang, Lu, Hu, Cheng, Wang, Ying, Mukhopadhyay, Debabrata, Radisky, Evette S., Zhang, Lizhi, Lugea, Aurelia, Pandol, Stephen J., Bi, Yan, Ji, Baoan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934224/
https://ncbi.nlm.nih.gov/pubmed/31550238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130172
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