Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1(R122H)

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRS...

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Udgivet i:J Clin Invest
Main Authors: Gui, Fu, Zhang, Yuebo, Wan, Jianhua, Zhan, Xianbao, Yao, Yao, Li, Yinghua, Haddock, Ashley N., Shi, Ji, Guo, Jia, Chen, Jiaxiang, Zhu, Xiaohui, Edenfield, Brandy H., Zhuang, Lu, Hu, Cheng, Wang, Ying, Mukhopadhyay, Debabrata, Radisky, Evette S., Zhang, Lizhi, Lugea, Aurelia, Pandol, Stephen J., Bi, Yan, Ji, Baoan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934224/
https://ncbi.nlm.nih.gov/pubmed/31550238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130172
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