Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1(R122H)

Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRS...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Gui, Fu, Zhang, Yuebo, Wan, Jianhua, Zhan, Xianbao, Yao, Yao, Li, Yinghua, Haddock, Ashley N., Shi, Ji, Guo, Jia, Chen, Jiaxiang, Zhu, Xiaohui, Edenfield, Brandy H., Zhuang, Lu, Hu, Cheng, Wang, Ying, Mukhopadhyay, Debabrata, Radisky, Evette S., Zhang, Lizhi, Lugea, Aurelia, Pandol, Stephen J., Bi, Yan, Ji, Baoan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934224/
https://ncbi.nlm.nih.gov/pubmed/31550238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130172
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