Transgenic Expression of PRSS1(R122H) Sensitizes Mice to Pancreatitis

BACKGROUND & AIMS: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied the effects of expressing mutant forms of human PRSS1 in mice. METHODS: We expressed forms of PRSS1 w...

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Xehetasun bibliografikoak
Argitaratua izan da:Gastroenterology
Egile Nagusiak: Huang, Haojie, Swidnicka-Siergiejko, Agnieszka Katarzyna, Daniluk, Jaroslaw, Gaiser, Sebastian, Yao, Yao, Peng, Lisi, Zhang, Yang, Liu, Yan, Dong, Minyu, Zhan, Xianbao, Wang, Huamin, Bi, Yan, Li, Zhaoshen, Ji, Baoan, Logsdon, Craig D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580257/
https://ncbi.nlm.nih.gov/pubmed/31419436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.08.016
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