Transgenic Expression of PRSS1(R122H) Sensitizes Mice to Pancreatitis

BACKGROUND & AIMS: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied the effects of expressing mutant forms of human PRSS1 in mice. METHODS: We expressed forms of PRSS1 w...

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Detaylı Bibliyografya
Yayımlandı:Gastroenterology
Asıl Yazarlar: Huang, Haojie, Swidnicka-Siergiejko, Agnieszka Katarzyna, Daniluk, Jaroslaw, Gaiser, Sebastian, Yao, Yao, Peng, Lisi, Zhang, Yang, Liu, Yan, Dong, Minyu, Zhan, Xianbao, Wang, Huamin, Bi, Yan, Li, Zhaoshen, Ji, Baoan, Logsdon, Craig D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580257/
https://ncbi.nlm.nih.gov/pubmed/31419436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.08.016
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