Transgenic Expression of PRSS1(R122H) Sensitizes Mice to Pancreatitis

BACKGROUND & AIMS: Mutations in the trypsinogen gene (PRSS1) cause human hereditary pancreatitis. However, it is not clear how mutant forms of PRSS1 contribute to disease development. We studied the effects of expressing mutant forms of human PRSS1 in mice. METHODS: We expressed forms of PRSS1 w...

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Publicado no:Gastroenterology
Principais autores: Huang, Haojie, Swidnicka-Siergiejko, Agnieszka Katarzyna, Daniluk, Jaroslaw, Gaiser, Sebastian, Yao, Yao, Peng, Lisi, Zhang, Yang, Liu, Yan, Dong, Minyu, Zhan, Xianbao, Wang, Huamin, Bi, Yan, Li, Zhaoshen, Ji, Baoan, Logsdon, Craig D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580257/
https://ncbi.nlm.nih.gov/pubmed/31419436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.08.016
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