Oridonin prevents insulin resistance–mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy

Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the pathogenesis of MHE. Oridonin (Ori) is an active terpenoid, which has been reported to rescue synaptic loss and restore insulin sensitivity. In this...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Wen, Fangfang, Zhuge, Weishan, Wang, Jian, Lu, Xiaoai, You, Ruimin, Liu, Leping, Zhuge, Qichuan, Ding, Saidan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933371/
https://ncbi.nlm.nih.gov/pubmed/31568638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14546
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