Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy

Minimal hepatic encephalopathy (MHE) is induced by elevated intracranial dopamine (DA). The relationship of the Shh pathway with memory loss in MHE, however, is elusive. In the current study, rats with MHE induced with DA displayed downregulation of the Shh pathway. Additionally, injection of Shh in...

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Detalhes bibliográficos
Publicado no:Aging Dis
Main Authors: Ding, Saidan, Yang, Jianjing, Huang, Xueli, Liu, Leping, Hu, Jiangnan, Xu, Zhu, Zhuge, Qichuan
Formato: Artigo
Idioma:Inglês
Publicado em: JKL International LLC 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524807/
https://ncbi.nlm.nih.gov/pubmed/28840059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2016.1123
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