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Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy

Minimal hepatic encephalopathy (MHE) is induced by elevated intracranial dopamine (DA). The relationship of the Shh pathway with memory loss in MHE, however, is elusive. In the current study, rats with MHE induced with DA displayed downregulation of the Shh pathway. Additionally, injection of Shh in...

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書誌詳細
出版年:Aging Dis
主要な著者: Ding, Saidan, Yang, Jianjing, Huang, Xueli, Liu, Leping, Hu, Jiangnan, Xu, Zhu, Zhuge, Qichuan
フォーマット: Artigo
言語:Inglês
出版事項: JKL International LLC 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524807/
https://ncbi.nlm.nih.gov/pubmed/28840059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2016.1123
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