Direct evidence for (G)O6···H(2)-N4(C)(+) hydrogen bonding in transient G(syn)-C(+) and G(syn)-m(5)C(+) Hoogsteen base pairs in duplex DNA from cytosine amino nitrogen off-resonance R(1ρ) relaxation dispersion measurements

NMR relaxation dispersion studies have shown that Watson-Crick G-C and A-T base pairs in duplex DNA exist in dynamic equilibrium with their Hoogsteen counterparts. Hoogsteen base pairs form through concurrent rotation of the purine base about the glycosidic bond from an anti to a syn conformation an...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Magn Reson
Auteurs principaux: Rangadurai, Atul, Kremser, Johannes, Shi, Honglue, Kreutz, Christoph, Al-Hashimi, Hashim M.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933314/
https://ncbi.nlm.nih.gov/pubmed/31539864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmr.2019.106589
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires