Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade

Primary mediastinal large B-cell lymphomas (PMBLs) are aggressive tumors that typically present as large mediastinal masses in young women. PMBLs share clinical, transcriptional, and molecular features with classical Hodgkin lymphoma (cHL), including constitutive activation of nuclear factor κB (NF-...

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Vydáno v:Blood
Hlavní autoři: Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Kim, Jaegil, Wienand, Kirsty, Kamburov, Atanas, Griffin, Gabriel K., Chen, Pei-Hsuan, Lako, Ana, Redd, Robert A., Cote, Claire M., Ducar, Matthew D., Thorner, Aaron R., Rodig, Scott J., Getz, Gad, Shipp, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933293/
https://ncbi.nlm.nih.gov/pubmed/31697821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002067
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