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Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL

Inhibition of the B-cell receptor (BCR) signaling pathway is a promising treatment strategy in multiple B-cell malignancies. However, the role of BCR blockade in diffuse large B-cell lymphoma (DLBCL) remains undefined. We recently characterized primary DLBCL subsets with distinct genetic bases for p...

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書誌詳細
出版年:Blood
主要な著者: Bojarczuk, Kamil, Wienand, Kirsty, Ryan, Jeremy A., Chen, Linfeng, Villalobos-Ortiz, Mariana, Mandato, Elisa, Stachura, Joanna, Letai, Anthony, Lawton, Lee N., Chapuy, Bjoern, Shipp, Margaret A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6318426/
https://ncbi.nlm.nih.gov/pubmed/30322870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-08-872465
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