CXCR4 upregulation is an indicator of sensitivity to B-cell receptor/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas

B-cell receptor (BCR) signaling pathway components represent promising treatment targets in multiple B-cell malignancies including diffuse large B-cell lymphoma (DLBCL). In in vitro and in vivo model systems, a subset of DLBCLs depend upon BCR survival signals and respond to proximal BCR/phosphoinos...

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Vydáno v:Haematologica
Hlavní autoři: Chen, Linfeng, Ouyang, Jing, Wienand, Kirsty, Bojarczuk, Kamil, Hao, Yansheng, Chapuy, Bjoern, Neuberg, Donna, Juszczynski, Przemyslaw, Lawton, Lee N., Rodig, Scott J., Monti, Stefano, Shipp, Margaret A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193488/
https://ncbi.nlm.nih.gov/pubmed/31471373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.216218
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