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Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade

Primary mediastinal large B-cell lymphomas (PMBLs) are aggressive tumors that typically present as large mediastinal masses in young women. PMBLs share clinical, transcriptional, and molecular features with classical Hodgkin lymphoma (cHL), including constitutive activation of nuclear factor κB (NF-...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Chapuy, Bjoern, Stewart, Chip, Dunford, Andrew J., Kim, Jaegil, Wienand, Kirsty, Kamburov, Atanas, Griffin, Gabriel K., Chen, Pei-Hsuan, Lako, Ana, Redd, Robert A., Cote, Claire M., Ducar, Matthew D., Thorner, Aaron R., Rodig, Scott J., Getz, Gad, Shipp, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6933293/
https://ncbi.nlm.nih.gov/pubmed/31697821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002067
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