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Single-cell analysis reveals regulatory gene expression dynamics leading to lineage commitment in early T cell development
Intrathymic T-cell development converts multipotent precursors to committed pro-T cells, silencing progenitor genes while inducing T-cell genes, but the underlying steps have remained obscure. Single-cell profiling was used to define the order of regulatory changes, employing single-cell RNA-seq for...
Gorde:
| Argitaratua izan da: | Cell Syst |
|---|---|
| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6932747/ https://ncbi.nlm.nih.gov/pubmed/31629685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.09.008 |
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