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Transcriptional establishment of cell-type identity: dynamics and causal mechanisms of T-cell lineage commitment

Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the closure of T-lineage commitment. As cells decide against the last alternative options to the T-cell fate, they turn on the transcription factor Bcl11b and silence expression of a group of multipotent pro...

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Autors principals: Rothenberg, Ellen V., Champhekar, Ameya, Damle, Sagar, Del Real, Marissa Morales, Kueh, Hao Yuan, Li, Long, Yui, Mary A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990665/
https://ncbi.nlm.nih.gov/pubmed/24135716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/sqb.2013.78.020271
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