A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

Cell fate decisions occur through the switch-like, irreversible activation of fate-specifying genes. These activation events are often assumed to be tightly coupled to changes in upstream transcription factors, but could also be constrained by cis-epigenetic mechanisms at individual gene loci. Here,...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Ng, Kenneth KH, Yui, Mary A, Mehta, Arnav, Siu, Sharmayne, Irwin, Blythe, Pease, Shirley, Hirose, Satoshi, Elowitz, Michael B, Rothenberg, Ellen V, Kueh, Hao Yuan
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Computational and Systems Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245732/
https://ncbi.nlm.nih.gov/pubmed/30457103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37851
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items