Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on the transcription factor Bcl11b. To clarify lineage commitment mechanisms, we followed developing T cells at single-cell level using Bcl11b knock-in fluorescent rep...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Kueh, Hao Yuan, Yui, Mary A., Ng, Kenneth K.H., Pease, Shirley S., Zhang, Jingli A., Damle, Sagar S., Freedman, George, Siu, Sharmayne, Bernstein, Irwin D., Elowitz, Michael B., Rothenberg, Ellen V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955789/
https://ncbi.nlm.nih.gov/pubmed/27376470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3514
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