Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on the transcription factor Bcl11b. To clarify lineage commitment mechanisms, we followed developing T cells at single-cell level using Bcl11b knock-in fluorescent rep...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Kueh, Hao Yuan, Yui, Mary A., Ng, Kenneth K.H., Pease, Shirley S., Zhang, Jingli A., Damle, Sagar S., Freedman, George, Siu, Sharmayne, Bernstein, Irwin D., Elowitz, Michael B., Rothenberg, Ellen V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955789/
https://ncbi.nlm.nih.gov/pubmed/27376470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3514
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