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Single-cell analysis reveals regulatory gene expression dynamics leading to lineage commitment in early T cell development

Intrathymic T-cell development converts multipotent precursors to committed pro-T cells, silencing progenitor genes while inducing T-cell genes, but the underlying steps have remained obscure. Single-cell profiling was used to define the order of regulatory changes, employing single-cell RNA-seq for...

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Dettagli Bibliografici
Pubblicato in:Cell Syst
Autori principali: Zhou, Wen, Yui, Mary A., Williams, Brian A., Yun, Jina, Wold, Barbara J., Cai, Long, Rothenberg, Ellen V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932747/
https://ncbi.nlm.nih.gov/pubmed/31629685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.09.008
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