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Mast cell diversion of T-lineage precursor cells by the essential T-lineage transcription factor GATA-3
GATA-3 is essential for T cell development from the earliest stages. However, highly abundant GATA-3 can drive T-lineage precursors to a non-T fate, depending on Notch signaling and developmental stage. GATA-3 overexpression blocked pro-T cell survival when Notch-Delta signals were present, but enha...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140173/ https://ncbi.nlm.nih.gov/pubmed/17603486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1486 |
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