Cargando...
Targeted Protein Degradation: Elements of PROTAC Design
Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the degradation of select proteins of interest (POIs) by hijacking the activity of E3 ubiquitin ligases for POI ubiquitination and subsequent deg...
Gardado en:
| Publicado en: | Curr Opin Chem Biol |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6930012/ https://ncbi.nlm.nih.gov/pubmed/31004963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.02.022 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|