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Targeted Protein Degradation: Elements of PROTAC Design
Targeted protein degradation using Proteolysis Targeting Chimeras (PROTACs) has emerged as a novel therapeutic modality in drug discovery. PROTACs mediate the degradation of select proteins of interest (POIs) by hijacking the activity of E3 ubiquitin ligases for POI ubiquitination and subsequent deg...
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| Publicado no: | Curr Opin Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6930012/ https://ncbi.nlm.nih.gov/pubmed/31004963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2019.02.022 |
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