In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects

Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dual agonist tesaglitazar to macrophages while reducing drug act...

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Gepubliceerd in:Theranostics
Hoofdauteurs: Osinski, Victoria, Bauknight, Dustin K., Dasa, Siva Sai Krishna, Harms, Matthew J., Kroon, Tobias, Marshall, Melissa A., Garmey, James C., Nguyen, Anh T., Hartman, Julia, Upadhye, Aditi, Srikakulapu, Prasad, Zhou, Andrea, O'Mahony, Gavin, Klibanov, Alexander L., Kelly, Kimberly A., Boucher, Jeremie, McNamara, Coleen A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ivyspring International Publisher 2020
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929996/
https://ncbi.nlm.nih.gov/pubmed/31903139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36572
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