In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects

Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dual agonist tesaglitazar to macrophages while reducing drug act...

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Библиографические подробности
Опубликовано в: :Theranostics
Главные авторы: Osinski, Victoria, Bauknight, Dustin K., Dasa, Siva Sai Krishna, Harms, Matthew J., Kroon, Tobias, Marshall, Melissa A., Garmey, James C., Nguyen, Anh T., Hartman, Julia, Upadhye, Aditi, Srikakulapu, Prasad, Zhou, Andrea, O'Mahony, Gavin, Klibanov, Alexander L., Kelly, Kimberly A., Boucher, Jeremie, McNamara, Coleen A.
Формат: Artigo
Язык:Inglês
Опубликовано: Ivyspring International Publisher 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929996/
https://ncbi.nlm.nih.gov/pubmed/31903139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36572
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