In vivo liposomal delivery of PPARα/γ dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects

Macrophages are important regulators of obesity-associated inflammation and PPARα and -γ agonism in macrophages has anti-inflammatory effects. In this study, we tested the efficacy with which liposomal delivery could target the PPARα/γ dual agonist tesaglitazar to macrophages while reducing drug act...

全面介紹

Na minha lista:
書目詳細資料
發表在:Theranostics
Main Authors: Osinski, Victoria, Bauknight, Dustin K., Dasa, Siva Sai Krishna, Harms, Matthew J., Kroon, Tobias, Marshall, Melissa A., Garmey, James C., Nguyen, Anh T., Hartman, Julia, Upadhye, Aditi, Srikakulapu, Prasad, Zhou, Andrea, O'Mahony, Gavin, Klibanov, Alexander L., Kelly, Kimberly A., Boucher, Jeremie, McNamara, Coleen A.
格式: Artigo
語言:Inglês
出版: Ivyspring International Publisher 2020
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929996/
https://ncbi.nlm.nih.gov/pubmed/31903139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36572
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍