The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

[Image: see text] β-Hydroxylation plays an important role in the nonribosomal peptide biosynthesis of many important natural products, including bleomycin, chloramphenicol, and the glycopeptide antibiotics (GPAs). Various oxidative enzymes have been implicated in such a process, with the mechanism o...

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Publicat a:ACS Chem Biol
Autors principals: Kaniusaite, Milda, Goode, Robert J. A., Schittenhelm, Ralf B., Makris, Thomas M., Cryle, Max J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929969/
https://ncbi.nlm.nih.gov/pubmed/31774267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00862
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