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The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

[Image: see text] β-Hydroxylation plays an important role in the nonribosomal peptide biosynthesis of many important natural products, including bleomycin, chloramphenicol, and the glycopeptide antibiotics (GPAs). Various oxidative enzymes have been implicated in such a process, with the mechanism o...

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Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Kaniusaite, Milda, Goode, Robert J. A., Schittenhelm, Ralf B., Makris, Thomas M., Cryle, Max J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929969/
https://ncbi.nlm.nih.gov/pubmed/31774267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00862
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