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The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis

[Image: see text] β-Hydroxylation plays an important role in the nonribosomal peptide biosynthesis of many important natural products, including bleomycin, chloramphenicol, and the glycopeptide antibiotics (GPAs). Various oxidative enzymes have been implicated in such a process, with the mechanism o...

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Detaylı Bibliyografya
Yayımlandı:ACS Chem Biol
Asıl Yazarlar: Kaniusaite, Milda, Goode, Robert J. A., Schittenhelm, Ralf B., Makris, Thomas M., Cryle, Max J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2019
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6929969/
https://ncbi.nlm.nih.gov/pubmed/31774267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00862
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