Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET

P-glycoprotein (P-gp, ABCB1) is an efflux transporter at the blood–brain barrier (BBB), which mediates clearance of beta-amyloid (Aβ) from brain into blood. We used (R)-[(11)C]verapamil PET in combination with partial P-gp inhibition with tariquidar to measure cerebral P-gp function in a beta-amyloi...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Zoufal, Viktoria, Wanek, Thomas, Krohn, Markus, Mairinger, Severin, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Pekar, Thomas, Bauer, Martin, Pahnke, Jens, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928546/
https://ncbi.nlm.nih.gov/pubmed/30354871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X18806640
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