Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

Background: ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) are co-localized at the blood-brain barrier (BBB), where they restrict the brain distribution of many different drugs. Moreover, ABCB1 and possibly ABCG2 play a role in Alzheimer’s disease (AD) by mediating the brain cle...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Wanek, Thomas, Zoufal, Viktoria, Brackhan, Mirjam, Krohn, Markus, Mairinger, Severin, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Pekar, Thomas, Pahnke, Jens, Langer, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7663372/
https://ncbi.nlm.nih.gov/pubmed/33153231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218245
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