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Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III(2) limits complex (C)I turnover, arguing again...

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Publicado en:Mol Cell
Main Authors: Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926478/
https://ncbi.nlm.nih.gov/pubmed/31492636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.022
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