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Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III(2) limits complex (C)I turnover, arguing again...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926478/
https://ncbi.nlm.nih.gov/pubmed/31492636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.022
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