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Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III(2) limits complex (C)I turnover, arguing again...

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Vydáno v:Mol Cell
Hlavní autoři: Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926478/
https://ncbi.nlm.nih.gov/pubmed/31492636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.022
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