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Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III(2) limits complex (C)I turnover, arguing again...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926478/
https://ncbi.nlm.nih.gov/pubmed/31492636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.022
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