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Structures of Respiratory Supercomplex I+III(2) Reveal Functional and Conformational Crosstalk

The mitochondrial electron transport chain complexes are organized into supercomplexes (SCs) of defined stoichiometry, which have been proposed to regulate electron flux via substrate channeling. We demonstrate that CoQ trapping in the isolated SC I+III(2) limits complex (C)I turnover, arguing again...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Letts, James A., Fiedorczuk, Karol, Degliesposti, Gianluca, Skehel, Mark, Sazanov, Leonid A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926478/
https://ncbi.nlm.nih.gov/pubmed/31492636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.022
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