Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements

Proteins of nuclear receptor subfamily 4 group A (NR4A), including NR4A1/NGFI-B, NR4A2/Nurr1, and NR4A3/NOR-1, are nuclear transcription factors that play important roles in metabolism, apoptosis, and proliferation. NR4A proteins recognize DNA response elements as monomers or dimers to regulate the...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Jiang, Longying, Dai, Shuyan, Li, Jun, Liang, Xujun, Qu, Lingzhi, Chen, Xiaojuan, Guo, Ming, Chen, Zhuchu, Chen, Lin, Wei, Hudie, Chen, Yongheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926456/
https://ncbi.nlm.nih.gov/pubmed/31723028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010730
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