In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subunit of the translation initiation factor eIF3 in the mouse l...

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Bibliografiske detaljer
Udgivet i:Mol Ther Nucleic Acids
Main Authors: Smekalova, Elena M., Gerashchenko, Maxim V., O’Connor, Patrick B.F., Whittaker, Charles A., Kauffman, Kevin J., Fefilova, Anna S., Zatsepin, Timofei S., Bogorad, Roman L., Baranov, Pavel V., Langer, Robert, Gladyshev, Vadim N., Anderson, Daniel G., Koteliansky, Victor
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926209/
https://ncbi.nlm.nih.gov/pubmed/31855834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.11.009
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