Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms

BACKGROUND AND AIMS: The Hippo pathway controls organ size through a negative regulation of the transcription co-activator Yap1. The overexpression of hyperactive mutant Yap1 or deletion of key components in the Hippo pathway leads to increased organ size in different species. Analysis of interactio...

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Publicado en:J Hepatol
Autores principales: Yin, Hao, Bogorad, Roman L., Barnes, Carmen, Walsha, Stephen, Zhuang, Iris, Nonaka, Hidenori, Ruda, Vera, Kuchimanchi, Satya, Nechev, Lubomir, Akinc, Akin, Xue, Wen, Zerial, Marino, Langer, Robert, Anderson, Daniel G., Koteliansky, Victor
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5381270/
https://ncbi.nlm.nih.gov/pubmed/26658687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.11.028
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