In Vivo RNAi-Mediated eIF3m Knockdown Affects Ribosome Biogenesis and Transcription but Has Limited Impact on mRNA-Specific Translation

Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subunit of the translation initiation factor eIF3 in the mouse l...

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Publicado no:Mol Ther Nucleic Acids
Main Authors: Smekalova, Elena M., Gerashchenko, Maxim V., O’Connor, Patrick B.F., Whittaker, Charles A., Kauffman, Kevin J., Fefilova, Anna S., Zatsepin, Timofei S., Bogorad, Roman L., Baranov, Pavel V., Langer, Robert, Gladyshev, Vadim N., Anderson, Daniel G., Koteliansky, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926209/
https://ncbi.nlm.nih.gov/pubmed/31855834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.11.009
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