Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes

Due to breakthroughs in RNAi and genome editing methods in the past decade, it is now easier than ever to study fine details of protein synthesis in animal models. However, most of our understanding of translation comes from unicellular organisms and cultured mammalian cells. In this study, we demon...

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Publicado no:Sci Rep
Main Authors: Gerashchenko, Maxim V., Nesterchuk, Mikhail V., Smekalova, Elena M., Paulo, Joao A., Kowalski, Piotr S., Akulich, Kseniya A., Bogorad, Roman, Dmitriev, Sergey E., Gygi, Steven, Zatsepin, Timofei, Anderson, Daniel G., Gladyshev, Vadim N., Koteliansky, Victor E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511953/
https://ncbi.nlm.nih.gov/pubmed/32968084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72399-4
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