The IκB-protein BCL-3 controls Toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus

Proinflammatory responses induced by Toll-like receptors (TLRs) are dependent on the activation of the NF-ĸB and mitogen-activated protein kinase (MAPK) pathways, which coordinate the transcription and synthesis of proinflammatory cytokines. We demonstrate that BCL-3, a nuclear IĸB protein that regu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Collins, Patricia E., Somma, Domenico, Kerrigan, David, Herrington, Felicity, Keeshan, Karen, Nibbs, Robert J. B., Carmody, Ruaidhrí J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926074/
https://ncbi.nlm.nih.gov/pubmed/31772019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900408116
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