IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases

The MEK-1/2 kinase TPL-2 is critical for Toll-like receptor activation of the ERK-1/2 MAP kinase pathway during inflammatory responses, but it can transform cells following C-terminal truncation. IκB kinase (IKK) complex phosphorylation of the TPL-2 C terminus regulates full-length TPL-2 activation...

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Detalhes bibliográficos
Main Authors: Ben-Addi, Abduelhakem, Mambole-Dema, Agnes, Brender, Christine, Martin, Stephen R., Janzen, Julia, Kjaer, Sven, Smerdon, Stephen J., Ley, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060680/
https://ncbi.nlm.nih.gov/pubmed/24912162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320440111
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