IκB Kinase 2 Regulates TPL-2 Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Direct Phosphorylation of TPL-2 Serine 400

Tumor progression locus 2 (TPL-2) functions as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular signal-regulated kinase 1 and 2 (ERK-1/2) mitogen-activated protein (MAP) kinases in lipopolysaccharide (LPS)-stimulated macrophages and for inducing the pr...

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Autors principals: Roget, Karine, Ben-Addi, Abduelhakem, Mambole-Dema, Agnes, Gantke, Thorsten, Yang, Huei-Ting, Janzen, Julia, Morrice, Nick, Abbott, Derek, Ley, Steven C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486174/
https://ncbi.nlm.nih.gov/pubmed/22988300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01065-12
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