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Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells
Engaging mammalian Toll-like receptors (TLRs) activate both the NF-κB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(−/−) cells, is required for extracellular signal-regulated kina...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413910/ https://ncbi.nlm.nih.gov/pubmed/16484370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511113103 |
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