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Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages

This study investigated responses to Toll-like receptor 2 (TLR2)-driven extracellular signal-related kinase (ERK) signaling in dendritic cells (DCs) versus macrophages. TLR2 signaling was induced with Pam(3)Cys-Ser-Lys(4), and the role of ERK signaling was interrogated pharmacologically with MEK1/2...

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Detalles Bibliográficos
Publicado en:Infect Immun
Main Authors: Groft, Sarah G., Nagy, Nancy, Boom, W. Henry, Harding, Clifford V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927937/
https://ncbi.nlm.nih.gov/pubmed/33077627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00323-20
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