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NF-κB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

The nuclear factor-κB (NF-κB) pathway is crucial for the survival of B cells stimulated through Toll-like receptors (TLRs). Here, we show that the heightened death of TLR4-activated nfkb1(−/−) B cells is the result of a failure of the Tpl(2)/MEK/ERK pathway to phosphorylate the proapo-ptotic BH3-onl...

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Autors principals: Banerjee, Ashish, Grumont, Raelene, Gugasyan, Raffi, White, Christine, Strasser, Andreas, Gerondakis, Steve
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400541/
https://ncbi.nlm.nih.gov/pubmed/18805964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-120832
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