An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

Deficiencies in either lamin B1 or lamin B2 cause both defective migration of cortical neurons in the developing brain and reduced neuronal survival. The neuronal migration abnormality is explained by a weakened nuclear lamina that interferes with nucleokinesis, a nuclear translocation process requi...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chen, Natalie Y., Yang, Ye, Weston, Thomas A., Belling, Jason N., Heizer, Patrick, Tu, Yiping, Kim, Paul, Edillo, Lovelyn, Jonas, Steven J., Weiss, Paul S., Fong, Loren G., Young, Stephen G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926041/
https://ncbi.nlm.nih.gov/pubmed/31796586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917225116
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