An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

Deficiencies in either lamin B1 or lamin B2 cause both defective migration of cortical neurons in the developing brain and reduced neuronal survival. The neuronal migration abnormality is explained by a weakened nuclear lamina that interferes with nucleokinesis, a nuclear translocation process requi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Chen, Natalie Y., Yang, Ye, Weston, Thomas A., Belling, Jason N., Heizer, Patrick, Tu, Yiping, Kim, Paul, Edillo, Lovelyn, Jonas, Steven J., Weiss, Paul S., Fong, Loren G., Young, Stephen G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926041/
https://ncbi.nlm.nih.gov/pubmed/31796586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917225116
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