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Energetic dependencies dictate folding mechanism in a complex protein

Large proteins with multiple domains are thought to fold cotranslationally to minimize interdomain misfolding. Once folded, domains interact with each other through the formation of extensive interfaces that are important for protein stability and function. However, multidomain protein folding and t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Kaixian, Chen, Xiuqi, Kaiser, Christian M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925980/
https://ncbi.nlm.nih.gov/pubmed/31776255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914366116
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