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Energetics and mechanisms of folding and flipping the myristoyl switch in the β-trefoil protein, hisactophilin

Myristoylation, the covalent linkage of a saturated, C(14) fatty acyl chain to the N-terminal glycine in a protein, plays a vital role in reversible membrane binding and signaling by the modified proteins. Currently, little is known about the effects of myristoylation on protein folding and stabilit...

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Bibliografiske detaljer
Main Authors: Smith, Martin T. J., Meissner, Joseph, Esmonde, Samantha, Wong, Hannah J., Meiering, Elizabeth M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000276/
https://ncbi.nlm.nih.gov/pubmed/21097705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008026107
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