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Synthesis runs counter to directional folding of a nascent protein domain
Folding of individual domains in large proteins during translation helps to avoid otherwise prevalent inter-domain misfolding. How folding intermediates observed in vitro for the majority of proteins relate to co-translational folding remains unclear. Combining in vivo and single-molecule experiment...
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| 發表在: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7547688/ https://ncbi.nlm.nih.gov/pubmed/33037221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18921-8 |
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