Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown. We characterize SERINC5 downregulation activity of 91 primary HIV-1 subtype B nef alleles, including isolates from 45 elite co...

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Publicat a:Cell Rep
Autors principals: Jin, Steven W., Alsahafi, Nirmin, Kuang, Xiaomei T., Swann, Shayda A., Toyoda, Mako, Göttlinger, Heinrich, Walker, Bruce D., Ueno, Takamasa, Finzi, Andrés, Brumme, Zabrina L., Brockman, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925589/
https://ncbi.nlm.nih.gov/pubmed/31693887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.007
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