Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

Clostridioides difficile is a leading cause of health care-associated infections. Although significant progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we performed a comprehensive DNA methy...

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Vydáno v:Nat Microbiol
Hlavní autoři: Oliveira, Pedro H., Ribis, John W., Garrett, Elizabeth M., Trzilova, Dominika, Kim, Alex, Sekulovic, Ognjen, Mead, Edward A., Pak, Theodore, Zhu, Shijia, Deikus, Gintaras, Touchon, Marie, Lewis-Sandari, Martha, Beckford, Colleen, Zeitouni, Nathalie E., Altman, Deena R., Webster, Elizabeth, Oussenko, Irina, Bunyavanich, Supinda, Aggarwal, Aneel K., Bashir, Ali, Patel, Gopi, Wallach, Frances, Hamula, Camille, Huprikar, Shirish, Schadt, Eric E., Sebra, Robert, van Bakel, Harm, Kasarskis, Andrew, Tamayo, Rita, Shen, Aimee, Fang, Gang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925328/
https://ncbi.nlm.nih.gov/pubmed/31768029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0613-4
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