Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis

Clostridioides difficile is a leading cause of health care-associated infections. Although significant progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we performed a comprehensive DNA methy...

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Pubblicato in:Nat Microbiol
Autori principali: Oliveira, Pedro H., Ribis, John W., Garrett, Elizabeth M., Trzilova, Dominika, Kim, Alex, Sekulovic, Ognjen, Mead, Edward A., Pak, Theodore, Zhu, Shijia, Deikus, Gintaras, Touchon, Marie, Lewis-Sandari, Martha, Beckford, Colleen, Zeitouni, Nathalie E., Altman, Deena R., Webster, Elizabeth, Oussenko, Irina, Bunyavanich, Supinda, Aggarwal, Aneel K., Bashir, Ali, Patel, Gopi, Wallach, Frances, Hamula, Camille, Huprikar, Shirish, Schadt, Eric E., Sebra, Robert, van Bakel, Harm, Kasarskis, Andrew, Tamayo, Rita, Shen, Aimee, Fang, Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925328/
https://ncbi.nlm.nih.gov/pubmed/31768029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0613-4
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